Selected Publications

 

Core Technology:

1. Ajani et al., 2006 Cancer 106: 1908-1916  Open-label, Multinational, Multicenter Study of G17DT Vaccination combined with Cisplatin and 5-Fluorouracil in patients with untreated, advanced gastric or gastroesphageal cancer: The GC4 Study

2. Gilliam et al., 2004 Eur. J. Surg. Oncol., 30: 536-543  A phase II study of G17DT in gastric carcinoma

3. Brett et al., 2002 J. Clin. Oncol., 20: 4225-4231  Phase II Study of Anti-gastrin-17 antibodies, raised to G17DT, in Advanced pancreatic cancer

4. Simms et al., 2000 Brit. J. Cancer 83: 443-446  Anti-GnRH antibodies can induce castrate levels of testosterone in patients with advanced prostate cancer

5. Smith et al., 2000 Clin. Cancer Res., 6: 4719-4724  Phase I/II study of G17DT, an anti-Gastrin immunogen, in advanced colorectal cancer

Type 1 Diabetes:

1. Orban, T. et al., “Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy,” J. of Autoimmunity 34 (2010) 408-415.

Alzheimer’s:

1. Lemere, C. A., et al., 2009  Society for Neuroscience, Chicago  Abstr# 211.13  A novel Th2-biased active ABeta vaccine conjugate, MER5101, generates high anti-ABeta titers and lowers cerebral plaque burden in AD-like transgenic mice

2. Lemere, C. A., et al., 2010 Netherlands Institute of Neuroscience A novel Th2-biased active ABeta vaccine conjugate, MER5101, generates high anti-ABeta titers and lowers cerebral plaque burden in AD-like transgenic mice

Asthma:

1. Grunig, G., et al., 2009 Keystone Symposium on Allergy and Asthma, Keystone CO., Development of a novel asthma vaccine that targets cytokines and chemokines

2. Grunig, G., et al., 2010 53rd annual Aspen Lung Conference, Aspen CO., Development of a novel asthma vaccine that targets cytokines and chemokines